IDEAS PET Imaging Study…Currently Enrolling

Description

The “IDEAS” Study stands for Imaging Dementia-Evidence for Amyloid Scanning. The purpose of this study is to improve the way doctors are able to take images of the brain and better treat dementia and memory-related conditions.

Over 8,000 medicare patients are expected to be in the study, and experienced scientists are conducting it with the Alzheimer’s Association and the American College of Radiology Imaging Network (ACRIN).

Body composition status and the risk of migraine

ABSTRACT

Objective: To evaluate the association between migraine and body composition status as estimated based on body mass index and WHO physical status categories.

 

Methods: Systematic electronic database searches were conducted for relevant studies. Two independent reviewers performed data extraction and quality appraisal. Odds ratios (OR) and confidence intervals (CI) were pooled using a random effects model.

Neuropsychiatric symptoms predict hypometabolism in preclinical Alzheimer disease

ABSTRACT

Objective: To identify regional brain metabolic dysfunctions associated with neuropsychiatric symptoms (NPS) in preclinical Alzheimer disease (AD).

 

Methods: We stratified 115 cognitively normal individuals into preclinical AD (both amyloid and tau pathologies present), asymptomatic at risk for AD (either amyloid or tau pathology present),

Parental family history of dementia in relation to subclinical brain disease and dementia risk

Objective: To determine the association of parental family history with risk of dementia by age at onset and sex of affected parent in a population-based cohort.

 

Methods: From 2000 to 2002, we assessed parental history of dementia in participants without dementia of the Rotterdam Study. We investigated associations of parental history with risk of dementia until 2015,

Blood-based NfL – A biomarker for differential diagnosis of parkinsonian disorder

Objective: To determine if blood neurofilament light chain (NfL) protein can discriminate between Parkinson disease (PD) and atypical parkinsonian disorders (APD) with equally high diagnostic accuracy as CSF NfL, and can therefore improve the diagnostic workup of parkinsonian disorders.

Methods: The study included 3 independent prospective cohorts: the Lund (n = 278) and London (n = 117) cohorts,

Left frontal cortex connectivity underlies cognitive reserve in prodromal Alzheimer disease

Objective: To test whether higher global functional connectivity of the left frontal cortex (LFC) in Alzheimer disease (AD) is associated with more years of education (a proxy of cognitive reserve [CR]) and mitigates the association between AD-related fluorodeoxyglucose (FDG)-PET hypometabolism and episodic memory.

Methods: Forty-four amyloid-PET–positive patients with amnestic mild cognitive impairment (MCI-Aβ+) and 24 amyloid-PET–negative healthy controls (HC) were included.

New Evidence that the Prevalence of Dementia is Declining

A new analysis of data from a database on persons aged 65 or older found that the prevalence of dementia went from 11.6 percent in 2000 to 8.8 percent in 2012, a decline attributed in part to an increase in educational attainment among the later-born group.

Researchers have long been warning about a coming tsunami of dementia as the population of older people grows,

Levels of Immune Marker TREM2 Rise Years Before Alzheimer’s Disease Becomes Apparent

Researchers reported that TREM2 levels rise early on in the progression of Alzheimer’s disease, and that the biomarker might be useful in clinical research to evaluate the benefits of new AD therapies on neuroinflammation, or may one day be a therapeutic target itself.

Levels of an immune cell receptor called TREM2 were found to increase early on in the progression of Alzheimer’s disease (AD),

Dementia risk in renal dysfunction

ABSTRACT

Objective: Renal dysfunction has been linked with increased risk for cognitive impairment and dementia, but studies are conflicting. For that reason, the aim of the present systematic review and meta-analysis is to summarize the best available evidence on the prospective association between potential markers of renal dysfunction and development of cognitive impairment or dementia.