Blood-based NfL – A biomarker for differential diagnosis of parkinsonian disorder

Objective: To determine if blood neurofilament light chain (NfL) protein can discriminate between Parkinson disease (PD) and atypical parkinsonian disorders (APD) with equally high diagnostic accuracy as CSF NfL, and can therefore improve the diagnostic workup of parkinsonian disorders.

Methods: The study included 3 independent prospective cohorts: the Lund (n = 278) and London (n = 117) cohorts,

Left frontal cortex connectivity underlies cognitive reserve in prodromal Alzheimer disease

Objective: To test whether higher global functional connectivity of the left frontal cortex (LFC) in Alzheimer disease (AD) is associated with more years of education (a proxy of cognitive reserve [CR]) and mitigates the association between AD-related fluorodeoxyglucose (FDG)-PET hypometabolism and episodic memory.

Methods: Forty-four amyloid-PET–positive patients with amnestic mild cognitive impairment (MCI-Aβ+) and 24 amyloid-PET–negative healthy controls (HC) were included.

New Evidence that the Prevalence of Dementia is Declining

A new analysis of data from a database on persons aged 65 or older found that the prevalence of dementia went from 11.6 percent in 2000 to 8.8 percent in 2012, a decline attributed in part to an increase in educational attainment among the later-born group.

Researchers have long been warning about a coming tsunami of dementia as the population of older people grows,

Levels of Immune Marker TREM2 Rise Years Before Alzheimer’s Disease Becomes Apparent

Researchers reported that TREM2 levels rise early on in the progression of Alzheimer’s disease, and that the biomarker might be useful in clinical research to evaluate the benefits of new AD therapies on neuroinflammation, or may one day be a therapeutic target itself.

Levels of an immune cell receptor called TREM2 were found to increase early on in the progression of Alzheimer’s disease (AD),

Dementia risk in renal dysfunction

ABSTRACT

Objective: Renal dysfunction has been linked with increased risk for cognitive impairment and dementia, but studies are conflicting. For that reason, the aim of the present systematic review and meta-analysis is to summarize the best available evidence on the prospective association between potential markers of renal dysfunction and development of cognitive impairment or dementia.

Dementia with Lewy bodies and Parkinson disease with dementia

The article by Thomas et al. validated 123I-FP-CIT dopaminergic neuroimaging for the diagnosis of autopsy-proven dementia with Lewy bodies (DLB). [1] The authors depicted 3 patients with DLB who met pathologic criteria for LBD but had normal 123I-FP-CIT imaging. [1] Although further description concerning severity of parkinsonism remains unclear, these patients may not have severe parkinsonism.

Doctor Tuchman’s Interview on Dementia with Lewy Bodies

Dr. Michael Tuchman was recently interviewed by the Palm Beach Post in regards to dementia with Lewy Bodies, or “DLB,” the effects it has and how it affected a Palm Beach Gardens couple. DLB is caused by the buildup of protein clusters in the brain and symptoms include rapid mood swings, insomnia and nightmares, hallucinations and memory loss.

Calcium Supplements May Be Associated with an Increased Risk for Dementia, Study Finds

Researchers reported an associated risk between calcium supplementation and the development of dementia in women with cerebrovascular disease. But the study authors and independent experts said the five-year population-based study sample was too small and the findings are premature and need to be replicated in a larger study.

Calcium supplements may raise the risk of dementia in elderly women with cerebrovascular disease,

Aerobic Exercise Found to Improve Cognition in Mild Vascular Cognitive Impairment

Investigators reported that, in a randomized controlled trial, patients with vascular cognitive impairment showed improvement on cognitive tests after participating in a six-month exercise program. Independent experts said the findings were promising, but preliminary.

Progressive aerobic-exercise training for six months appeared to improve cognition in adults with mild subcortical ischemic vascular cognitive impairment,