Left frontal cortex connectivity underlies cognitive reserve in prodromal Alzheimer disease

Objective: To test whether higher global functional connectivity of the left frontal cortex (LFC) in Alzheimer disease (AD) is associated with more years of education (a proxy of cognitive reserve [CR]) and mitigates the association between AD-related fluorodeoxyglucose (FDG)-PET hypometabolism and episodic memory.

Methods: Forty-four amyloid-PET–positive patients with amnestic mild cognitive impairment (MCI-Aβ+) and 24 amyloid-PET–negative healthy controls (HC) were included.

Levels of Immune Marker TREM2 Rise Years Before Alzheimer’s Disease Becomes Apparent

Researchers reported that TREM2 levels rise early on in the progression of Alzheimer’s disease, and that the biomarker might be useful in clinical research to evaluate the benefits of new AD therapies on neuroinflammation, or may one day be a therapeutic target itself.

Levels of an immune cell receptor called TREM2 were found to increase early on in the progression of Alzheimer’s disease (AD),

Calcium Supplements May Be Associated with an Increased Risk for Dementia, Study Finds

Researchers reported an associated risk between calcium supplementation and the development of dementia in women with cerebrovascular disease. But the study authors and independent experts said the five-year population-based study sample was too small and the findings are premature and need to be replicated in a larger study.

Calcium supplements may raise the risk of dementia in elderly women with cerebrovascular disease,

Distinct brain networks underlie cognitive dysfunction in Parkinson and Alzheimer diseases

Objective: To determine whether cognitive impairment in Parkinson disease (PD) and Alzheimer disease (AD) derives from the same network pathology.

Methods: We analyzed 18F-fluorodeoxyglucose PET scans from 40 patients with AD and 40 age-matched healthy controls from the Alzheimer’s Disease Neuroimaging Initiative and scanned an additional 10 patients with AD and 10 healthy controls at The Feinstein Institute for Medical Research to derive an AD-related metabolic pattern (ADRP) analogous to our previously established PD cognition-related pattern (PDCP) and PD motor-related pattern (PDRP).

Potential Treatment for Early Onset Alzheimer’s…Currently Enrolling

Description

A global clinical research study assessing the effectiveness and safety of an investigational medication designed to slow the progression of early Alzheimer’s disease.

The ENGAGE study is split into two phases: a placebo-controlled phase, and an optional long-term extension phase.

In the placebo-controlled phase, eligible participants will have a 2-in-3 chance of receiving the investigational medication and a 1-in-3 chance of receiving the placebo.

Eisai / Mild Cognitive Impairment or Mild Alzheimer’s Disease

Eisai / Mild Cognitive Impairment or Mild Alzheimer’s Disease…Ongoing Study

What is Mild Cognitive Impairment (MCI)?

Mild Cognitive Impairment is a condition in which a person has memory loss or thinking problems that are worse than those caused by normal aging, but not bad enough to interfere with daily activities.  A person with MCI has a higher risk of developing Alzheimer’s disease,

Alzheimer’s Research Study

Several treatments are available to help ease Alzheimer’s symptoms; however, none of these existing treatments are capable of slowing the progression of the disease and protecting the brain from further damage. Clinical researches are developing new treatments that may slow the progression of Alzheimer’s.

The SUVN-502 Study is to test whether an investigational medication,

4 Main Areas of Concern in Late-Stage Alzheimer’s Disease and How Caretakers Can Address Them

Late-stage Alzheimer’s disease (AD) is extremely difficult for both the patient and the caretaker. The caretaker is forced to watch as their loved one’s cognitive and physical abilities slowly decline. It is physically and emotionally draining.

Knowing your major concern areas ahead of time can help you deal with these issues better once your loved one reaches that point.

What to do When Your Loved One Has Been Diagnosed with Alzheimer’s Disease

Learning that your loved one has been diagnosed with Alzheimer’s disease can be a very difficult experience. Learning about the stages and treatments of the disease, and helping to plan for the future are all daunting tasks. While the primary focus tends to be on the patient, it is equally important for the family and caregivers to take care of themselves.

Preparing for the Advanced Stages of Alzheimer’s Disease

If you have just been diagnosed with early-stage Alzheimer’s disease (AD), you may be wondering what your next steps should be. This is a frightening time, but preparation will make the disease’s progression much easier on you and your family. This blog outlines the major concerns that you will face in the latest stage of AD.