Author Archive: Neurology Patient Care & Research

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Potential Treatment for Early Onset Alzheimer’s…Currently Enrolling

By | December 26, 2017 | Alzheimer's Disease, Current Research Studies, General | Like |

Description

A global clinical research study assessing the effectiveness and safety of an investigational medication designed to slow the progression of early Alzheimer’s disease.

The ENGAGE study is split into two phases: a placebo-controlled phase, and an optional long-term extension phase.

In the placebo-controlled phase, eligible participants will have a 2-in-3 chance of receiving the investigational medication and a 1-in-3 chance of receiving the placebo.

The MissionAD study for early stages of Alzheimer’s disease…Currently Enrolling

By | October 12, 2017 | Current Research Studies | Like |

Description

The MissionAD study program is a clinical research program testing an investigational drug for the early stages of Alzheimer’s disease. (“Investigational” means the drug isn’t yet approved for use by the public.) Doctors are studying this investigational drug to make sure it is safe and to see if it may help people with Alzheimer’s disease in the future.

Behavioral-variant frontotemporal dementia

By | August 31, 2017 | Dementia | 1 |

ABSTRACT

Objective: To identify distinct behavioral phenotypes of behavioral-variant frontotemporal dementia (bvFTD) and to elucidate differences in functional, neuroimaging, and progression to residential care placement.

Methods: Eighty-eight patients with bvFTD were included in a cluster analysis applying levels of disinhibition and apathy (Cambridge Behavioural Inventory-Revised) to identify phenotypic subgroups. Between-group (Kruskal-Wallis,

Rethinking cognition in Parkinson disease – Phosphodiesterase 4

By | August 16, 2017 | Parkinson's Disease | Like |

The nosology and treatment options for cognitive impairment in Parkinson disease (PD) remains perhaps the greatest unmet clinical need.1 The reported frequency of mild cognitive impairment (MCI) in newly diagnosed PD has ranged from 22% to 43%.2,3 A proportion of those with PD-MCI progress to PD dementia (PDD), the prevalence of which is variously estimated between 24% and 31%,

Slowing gait and risk for cognitive impairment

By | August 8, 2017 | Dementia | Like |

Originally posted on www.neurology.org

Methods: We assessed a cohort of older adults (n = 175, mean age 73 years, 57% female, 65% white) with repeated measures of gait speed over 14 years, MRI for gray matter volume (GMV) at year 10 or 11, and adjudicated cognitive status at year 14. Gait slowing was calculated by bayesian slopes corrected for intercepts,

Dementia with Lewy bodies: Diagnosis is only skin deep?

By | July 25, 2017 | DLB | Like |

Originally posted on www.neurology.org

Dementia with Lewy bodies (DLB) is currently diagnosed clinically by identifying dementia in combination with a number of hallmark features: REM sleep behavior disorder (RBD), prominent visual hallucinations, parkinsonism, and marked fluctuations of cognition and alertness.1 DLB is often underdiagnosed, suggesting a role for biomarkers. The main differential diagnosis of DLB is Alzheimer disease (AD);

IDEAS PET Imaging Study…Ongoing Study

By | June 6, 2017 | Current Research Studies | Like |

Description

The “IDEAS” Study stands for Imaging Dementia-Evidence for Amyloid Scanning. The purpose of this study is to improve the way doctors are able to take images of the brain and better treat dementia and memory-related conditions.

Over 8,000 medicare patients are expected to be in the study, and experienced scientists are conducting it with the Alzheimer’s Association and the American College of Radiology Imaging Network (ACRIN).

Body composition status and the risk of migraine

By | May 23, 2017 | Migraine Headaches | Like |

ABSTRACT

Objective: To evaluate the association between migraine and body composition status as estimated based on body mass index and WHO physical status categories.

 

Methods: Systematic electronic database searches were conducted for relevant studies. Two independent reviewers performed data extraction and quality appraisal. Odds ratios (OR) and confidence intervals (CI) were pooled using a random effects model.

Neuropsychiatric symptoms predict hypometabolism in preclinical Alzheimer disease

By | May 16, 2017 | Alzheimer's Disease | Like |

ABSTRACT

Objective: To identify regional brain metabolic dysfunctions associated with neuropsychiatric symptoms (NPS) in preclinical Alzheimer disease (AD).

 

Methods: We stratified 115 cognitively normal individuals into preclinical AD (both amyloid and tau pathologies present), asymptomatic at risk for AD (either amyloid or tau pathology present),

Parental family history of dementia in relation to subclinical brain disease and dementia risk

By | May 9, 2017 | General | Like |

Objective: To determine the association of parental family history with risk of dementia by age at onset and sex of affected parent in a population-based cohort.

 

Methods: From 2000 to 2002, we assessed parental history of dementia in participants without dementia of the Rotterdam Study. We investigated associations of parental history with risk of dementia until 2015,

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