Dementia with Lewy bodies: Diagnosis is only skin deep?

Originally posted on www.neurology.org

Dementia with Lewy bodies (DLB) is currently diagnosed clinically by identifying dementia in combination with a number of hallmark features: REM sleep behavior disorder (RBD), prominent visual hallucinations, parkinsonism, and marked fluctuations of cognition and alertness.1 DLB is often underdiagnosed, suggesting a role for biomarkers. The main differential diagnosis of DLB is Alzheimer disease (AD);

Dementia with Lewy bodies and Parkinson disease with dementia

The article by Thomas et al. validated 123I-FP-CIT dopaminergic neuroimaging for the diagnosis of autopsy-proven dementia with Lewy bodies (DLB). [1] The authors depicted 3 patients with DLB who met pathologic criteria for LBD but had normal 123I-FP-CIT imaging. [1] Although further description concerning severity of parkinsonism remains unclear, these patients may not have severe parkinsonism.