Description Palm Beach Neurological Center is participating in a global clinical research study to prevent or delay Alzheimer’s disease in cognitively healthy, older individuals that have been identified with one or two major genetic risk factors for the onset of Alzheimer’s disease. The Generation Study 2 is...
Description A global clinical research study assessing the effectiveness and safety of an investigational medication designed to slow the progression of early Alzheimer’s disease. The ENGAGE study is split into two phases: a placebo-controlled phase, and an optional long-term extension phase. In the placebo-controlled phase, eligible participants will...
Description The MissionAD study program is a clinical research program testing an investigational drug for the early stages of Alzheimer’s disease. (“Investigational” means the drug isn’t yet approved for use by the public.) Doctors are studying this investigational drug to make sure it is safe and...
The nosology and treatment options for cognitive impairment in Parkinson disease (PD) remains perhaps the greatest unmet clinical need. [1] The reported frequency of mild cognitive impairment (MCI) in newly diagnosed PD has ranged from 22% to 43%. [2,3] A proportion of those with PD-MCI...
Originally posted on www.neurology.org Methods: We assessed a cohort of older adults (n = 175, mean age 73 years, 57% female, 65% white) with repeated measures of gait speed over 14 years, MRI for gray matter volume (GMV) at year 10 or 11, and adjudicated cognitive...
Originally posted on www.neurology.org Dementia with Lewy bodies (DLB) is currently diagnosed clinically by identifying dementia in combination with a number of hallmark features: REM sleep behavior disorder (RBD), prominent visual hallucinations, parkinsonism, and marked fluctuations of cognition and alertness.1 DLB is often underdiagnosed, suggesting a...
Description The "IDEAS" Study stands for Imaging Dementia-Evidence for Amyloid Scanning. The purpose of this study is to improve the way doctors are able to take images of the brain and better treat dementia and memory-related conditions. Over 8,000 medicare patients are expected to be in the study,...
ABSTRACT Objective: To evaluate the association between migraine and body composition status as estimated based on body mass index and WHO physical status categories. Methods: Systematic electronic database searches were conducted for relevant studies. Two independent reviewers performed data extraction and quality appraisal. Odds ratios (OR) and...
ABSTRACT Objective: To identify regional brain metabolic dysfunctions associated with neuropsychiatric symptoms (NPS) in preclinical Alzheimer disease (AD). Methods: We stratified 115 cognitively normal individuals into preclinical AD (both amyloid and tau pathologies present), asymptomatic at risk for AD (either amyloid or tau pathology present), or healthy...
Objective: To determine the association of parental family history with risk of dementia by age at onset and sex of affected parent in a population-based cohort. Methods: From 2000 to 2002, we assessed parental history of dementia in participants without dementia of the Rotterdam Study. We...