ABSTRACT Objective: To identify regional brain metabolic dysfunctions associated with neuropsychiatric symptoms (NPS) in preclinical Alzheimer disease (AD). Methods: We stratified 115 cognitively normal individuals into preclinical AD (both amyloid and tau pathologies present), asymptomatic at risk for AD (either amyloid or tau pathology present), or healthy...
Objective: To determine the association of parental family history with risk of dementia by age at onset and sex of affected parent in a population-based cohort. Methods: From 2000 to 2002, we assessed parental history of dementia in participants without dementia of the Rotterdam Study. We...
Objective: Prior studies indicate that olfactory function may be an early marker for cognitive impairment, but the body of evidence has been largely restricted to white populations. Methods: We studied 2,428 community-dwelling black and white older adults (baseline age 70–79 years) without dementia enrolled in the...
Objective: To determine if blood neurofilament light chain (NfL) protein can discriminate between Parkinson disease (PD) and atypical parkinsonian disorders (APD) with equally high diagnostic accuracy as CSF NfL, and can therefore improve the diagnostic workup of parkinsonian disorders. Methods: The study included 3 independent prospective...
Objective: To test whether higher global functional connectivity of the left frontal cortex (LFC) in Alzheimer disease (AD) is associated with more years of education (a proxy of cognitive reserve [CR]) and mitigates the association between AD-related fluorodeoxyglucose (FDG)-PET hypometabolism and episodic memory. Methods: Forty-four amyloid-PET–positive...
A new analysis of data from a database on persons aged 65 or older found that the prevalence of dementia went from 11.6 percent in 2000 to 8.8 percent in 2012, a decline attributed in part to an increase in educational attainment among the later-born...
Researchers reported that TREM2 levels rise early on in the progression of Alzheimer's disease, and that the biomarker might be useful in clinical research to evaluate the benefits of new AD therapies on neuroinflammation, or may one day be a therapeutic target itself. Levels of an...
ABSTRACT Objective: Renal dysfunction has been linked with increased risk for cognitive impairment and dementia, but studies are conflicting. For that reason, the aim of the present systematic review and meta-analysis is to summarize the best available evidence on the prospective association between potential markers of...
Description Many people who have Alzheimer’s also have irregular patterns of sleeping at night and napping during the day. A clinical research study is studying an investigational medication in people with Alzheimer’s disease and sleep problems. Qualified study volunteers may receive: Study medication Study-related medical care Transportation...
The article by Thomas et al. validated 123I-FP-CIT dopaminergic neuroimaging for the diagnosis of autopsy-proven dementia with Lewy bodies (DLB). [1] The authors depicted 3 patients with DLB who met pathologic criteria for LBD but had normal 123I-FP-CIT imaging. [1] Although further description concerning severity...