ABSTRACT Objective: To determine whether poor cardiovascular (CV) fitness and exaggerated exercise blood pressure (BP) and heart rate (HR) were associated with worse brain morphology in later life. Methods: Framingham Offspring participants (n = 1,094, 53.9% female) free from dementia and CV disease (CVD) underwent an exercise...
ABSTRACT Objective: To evaluate the association between the presence of integrated systems of stroke care and stroke case-fatality across Canada. Methods: We used the Canadian Institute of Health Information's Discharge Abstract Database to retrospectively identify a cohort of stroke/TIA patients admitted to all acute care hospitals, excluding...
ABSTRACT Objective: To investigate the role of multiple distributed brain networks, including the default mode, fronto-temporo-parietal, and cingulo-opercular networks, which mediate domain-general and task-specific processes during speech production after aphasic stroke. Methods: We conducted an observational functional MRI study to investigate the effects of a previous left...
ABSTRACT Objectives: We investigated the correlation between polygenic risk of ischemic stroke (and its subtypes) and cognitive ability in 3 relatively healthy Scottish cohorts: the Lothian Birth Cohort 1936 (LBC1936), the Lothian Birth Cohort 1921 (LBC1921), and Generation Scotland: Scottish Family Health Study (GS). Methods: Polygenic risk...
A Randomized, Placebo controlled, Double-Blind Clinical Trial to Study the Efficacy and Safety of MK-8931 in Subjects with Amnestic Mild Cognitive Impairment Due to Alzheimer's Disease. (Prodromal AD) This is an 18 month study in which subjects that screen and qualify will go onto the program...
Late-stage Alzheimer’s disease (AD) is extremely difficult for both the patient and the caretaker. The caretaker is forced to watch as their loved one’s cognitive and physical abilities slowly decline. It is physically and emotionally draining. Knowing your major concern areas ahead of time can help...
Learning that your loved one has been diagnosed with Alzheimer’s disease can be a very difficult experience. Learning about the stages and treatments of the disease, and helping to plan for the future are all daunting tasks. While the primary focus tends to be on...
If you have just been diagnosed with early-stage Alzheimer’s disease (AD), you may be wondering what your next steps should be. This is a frightening time, but preparation will make the disease’s progression much easier on you and your family. This blog outlines the major...
Alzheimer’s disease is progressive, and it is often classified into several stages. These stages are simply known as Early stage, Mid-stage, and Late stage. Sometimes these stages are broken down even further. None of the stages have a specific time length, and the time spent...
The early stages of Alzheimer’s are marked with significant behavioral changes. Friends and family will likely notice behavioral changes long before the patient does. Behavioral changes are often gradual and subtle, and they increase as the disease progresses. Mild cognitive impairment (MCI) is almost a...